{"product_id":"cjc-1295-without-dac-5mg","title":"CJC-1295 without DAC","description":"\u003ch3\u003eProduct Overview\u003c\/h3\u003e\u003cp\u003eCJC-1295 without DAC is a synthetic analogue of growth hormone-releasing hormone (GHRH) consisting of the first 29 amino acids of GHRH with four amino acid substitutions to prevent degradation by dipeptidyl peptidase IV (DPP-IV) and aminopeptidases. This modification significantly extends the peptide's half-life compared to native GHRH while maintaining its biological activity.\u003c\/p\u003e\u003ch3\u003eMolecular Specifications\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C152H252N44O42\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 3367.97 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence Length:\u003c\/strong\u003e 30 amino acids\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAppearance:\u003c\/strong\u003e White lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water and bacteriostatic water\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eStructural Modifications\u003c\/h3\u003e\u003cp\u003eThe key modifications include substitutions at positions 2, 8, 15, and 27 of the native GHRH sequence:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eD-Ala² substitution for enhanced stability\u003c\/li\u003e\n\u003cli\u003eGln⁸ substitution to prevent DPP-IV cleavage\u003c\/li\u003e\n\u003cli\u003eAla¹⁵ substitution for improved receptor binding\u003c\/li\u003e\n\u003cli\u003eLeu²⁷ substitution for increased half-life\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eResearch Applications\u003c\/h3\u003e\u003cp\u003eThis compound is utilised in various research contexts investigating:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eGrowth hormone releasing hormone receptor pharmacology\u003c\/li\u003e\n\u003cli\u003ePituitary somatotroph cell function and signalling\u003c\/li\u003e\n\u003cli\u003eGrowth hormone secretion dynamics and pulsatility\u003c\/li\u003e\n\u003cli\u003ePeptide stability and degradation pathways\u003c\/li\u003e\n\u003cli\u003eReceptor-ligand interaction studies\u003c\/li\u003e\n\u003cli\u003eComparative pharmacokinetic analysis with DAC variants\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eStorage \u0026amp; Handling\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage Temperature:\u003c\/strong\u003e -20°C (lyophilised), 2-8°C (reconstituted, short-term)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e 24 months lyophilised, 30 days reconstituted at 2-8°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Use sterile water or bacteriostatic water\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHalf-life:\u003c\/strong\u003e Approximately 30 minutes (shorter than DAC variant)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eQuality Assurance\u003c\/h3\u003e\u003cp\u003eEach batch undergoes comprehensive analytical testing including HPLC purity analysis, mass spectrometry verification, amino acid analysis, and endotoxin testing. Certificate of Analysis provided with each shipment.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFor research purposes only. Not for human consumption or therapeutic use.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Peptidal","offers":[{"title":"2mg","offer_id":55256771658076,"sku":"CJC-NODAC-5MG-001","price":18.0,"currency_code":"GBP","in_stock":false},{"title":"5mg","offer_id":55256771690844,"sku":"CJC-NODAC-5MG-002","price":38.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0943\/7632\/9564\/files\/CJC-1295_Without_DAC_2mg.png?v=1778845058","url":"https:\/\/shop.peptidal.co.uk\/products\/cjc-1295-without-dac-5mg","provider":"Peptidal","version":"1.0","type":"link"}